AnaSpec Introduces Histone GO™ Peptides - Acetylated & Methylated

San Jose, CA, October 11, 2008 --(PR.com)-- The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds. Covalent modification on the amino terminal of the core histones through de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and exquisitely regulate gene expression.1-3 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.2
AnaSpec, one of the world’s largest provider of on-demand peptides is pleased to announce the rapid expansion of their histone peptide selection. Histone GO™ Peptides include sequences that are acetylated and di- or tri-methylated.
About AnaSpec

AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

For more information visit www.anaspec.com
References:
1. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
2. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
3. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).

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