Tocomin®SupraBio™ Boosts Immune Response in Human
Tocomin®SupraBio™ bioenhanced palm tocotrienol complex is effective in enhancing immune function in healthy women.
Edison, NJ, October 22, 2010 --(PR.com)-- Carotech Inc., the world’s largest GMP-certified palm tocotrienol complex producer, is pleased to share results from a human trial that shows its Tocomin®SupraBio™ bioenhanced palm tocotrienol complex supplementation improves immune response and function in healthy women volunteers post vaccination.
Published in the European Journal of Clinical Nutrition, researchers at the Malaysian Palm Oil Board, International Medical University and University Putra Malaysia conducted this randomized, double-blind, placebo-controlled human trial to evaluate potential effects of palm tocotrienol complex during immunization.
A total of 108 healthy non-smoking women aged between 18 and 25 years were recruited for this study. Randomly assigned to 2 groups, volunteers in the supplemented group were given 2 x 200 mg of palm tocotrienol complex and for control group, 2 x 200 mg of soy oil (placebo) capsules per day for 2 months. The palm tocotrienol capsules were manufactured by Hovid Berhad and contain Tocomin®SupraBio™ having 62 mg alpha-tocotrienol, 113 mg gamma-tocotrienol, 26 mg delta-tocotrienol and 92IU of alpha-tocopherol.
Blood samples were taken and analyzed at 0, 28 and 56 days. On Day 28, these volunteers received a single shot of tetanus toxoid (TT) vaccine after their blood was drawn. Subsequent blood test done at the end of the study period (56 day) revealed that levels of anti-TT antibody, interferon (IFN)-gamma and interleukin (IL)-4 in the supplemented group were significantly elevated post vaccination compared to control. Increased production of IFN-gamma and IL-4 indicates a positive cell-mediated immune response leading to much higher concentration of anti-TT IgG Antibody. At the same time, production of pro-inflammatory marker interleukin (IL)-6 in the supplemented group was significantly suppressed compared to control.
In addition, the researchers also documented significantly increased plasma levels of tocotrienol (T3) isomers in the supplemented group compared with controls on days 28 and 56. The concentration of T3 isomers found in the plasma is alpha-T3 > gamma-T3 > delta-T3. This result once again confirms the previous published observation that alpha-tocotrienol has the highest absolute oral bioavailability, followed by gamma-tocotrienol. Delta-tocotrienol has the lowest bioavailability.
“This randomized, double-blinded, placebo-controlled clinical trial shows that the bioenhanced palm tocotrienol complex from Tocomin®SupraBio™ is effective in triggering enhanced immune response in healthy human towards tetanus toxoid vaccine. It opens up a new application of Tocomin®SupraBio™ in supporting immune function in healthy individuals,” says Dr. Sharon Ling, Vice President, Scientific Affairs, Carotech Bhd.
“We are exceedingly pleased to know that Tocomin®SupraBio™ supports and improves the immune function. Carotech is the only GMP-certified tocotrienol producer in the world and our Tocomin® and Tocomin®SupraBio™ ingredients are produced according to pharmaceutical GMP guidelines and hence our customer are assured of the highest level of quality and purity products,” added WH Leong, Vice President, Carotech Inc.
Source:
D Mahalingam, AK Radhakrishnan, Z Amom, N Ibrahim and K Nesaretnam, “Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers”, European Journal of Clinical Nutrition (2010). Doi:10.1038/ejcn.2010.184
About Carotech Inc.
Carotech, incorporated in 1990, is a public listed company in Malaysia (ACE Market). It was the first producer in the world of natural full spectrum tocotrienol/tocopherol complex (Tocomin® & Tocomin®SupraBio™), natural mixed carotene complex (Caromin®) and phytosterol complex (Stelessterol™) via its patented technology (US Patent Nos. 5,157,132 & 7,544,822).
Besides being the largest producer of tocotrienol, Carotech is also the only GMP-Certified tocotrienol producer in the world.
Tocomin®SupraBio™ is a patented (US Patent No. 6,596,306) self emulsifying palm tocotrienol complex that ensures optimal tocotrienols oral absorption.
Carotech is a subsidiary of Hovid Ltd (www.hovid.com), one of the largest GMP-certified pharmaceutical companies in Malaysia.
Carotech manufactures these products under the tradenames: Tocomin®, Tocomin®SupraBio™, Caromin® and Stelessterol™.
Websites: www.carotech.net and www.tocotrienol.org
Contacts:
Mr. Bryan See, Regional Product Manager, Carotech Inc, USA. Tel: +1(732) 906 1901
E-mail : klsee@carotech.net
Dr Sharon Ling, Vice President, Scientific Affairs, Europe Sales and Marketing. Tel : +44 (0) 1296 623 214
E-mail : sling@carotech.net
Mr WH Leong, Vice President, Carotech Pty. Ltd (Australia). Tel : +61 (03) 98013881
E-mail : carot3@aol.com
###
Published in the European Journal of Clinical Nutrition, researchers at the Malaysian Palm Oil Board, International Medical University and University Putra Malaysia conducted this randomized, double-blind, placebo-controlled human trial to evaluate potential effects of palm tocotrienol complex during immunization.
A total of 108 healthy non-smoking women aged between 18 and 25 years were recruited for this study. Randomly assigned to 2 groups, volunteers in the supplemented group were given 2 x 200 mg of palm tocotrienol complex and for control group, 2 x 200 mg of soy oil (placebo) capsules per day for 2 months. The palm tocotrienol capsules were manufactured by Hovid Berhad and contain Tocomin®SupraBio™ having 62 mg alpha-tocotrienol, 113 mg gamma-tocotrienol, 26 mg delta-tocotrienol and 92IU of alpha-tocopherol.
Blood samples were taken and analyzed at 0, 28 and 56 days. On Day 28, these volunteers received a single shot of tetanus toxoid (TT) vaccine after their blood was drawn. Subsequent blood test done at the end of the study period (56 day) revealed that levels of anti-TT antibody, interferon (IFN)-gamma and interleukin (IL)-4 in the supplemented group were significantly elevated post vaccination compared to control. Increased production of IFN-gamma and IL-4 indicates a positive cell-mediated immune response leading to much higher concentration of anti-TT IgG Antibody. At the same time, production of pro-inflammatory marker interleukin (IL)-6 in the supplemented group was significantly suppressed compared to control.
In addition, the researchers also documented significantly increased plasma levels of tocotrienol (T3) isomers in the supplemented group compared with controls on days 28 and 56. The concentration of T3 isomers found in the plasma is alpha-T3 > gamma-T3 > delta-T3. This result once again confirms the previous published observation that alpha-tocotrienol has the highest absolute oral bioavailability, followed by gamma-tocotrienol. Delta-tocotrienol has the lowest bioavailability.
“This randomized, double-blinded, placebo-controlled clinical trial shows that the bioenhanced palm tocotrienol complex from Tocomin®SupraBio™ is effective in triggering enhanced immune response in healthy human towards tetanus toxoid vaccine. It opens up a new application of Tocomin®SupraBio™ in supporting immune function in healthy individuals,” says Dr. Sharon Ling, Vice President, Scientific Affairs, Carotech Bhd.
“We are exceedingly pleased to know that Tocomin®SupraBio™ supports and improves the immune function. Carotech is the only GMP-certified tocotrienol producer in the world and our Tocomin® and Tocomin®SupraBio™ ingredients are produced according to pharmaceutical GMP guidelines and hence our customer are assured of the highest level of quality and purity products,” added WH Leong, Vice President, Carotech Inc.
Source:
D Mahalingam, AK Radhakrishnan, Z Amom, N Ibrahim and K Nesaretnam, “Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers”, European Journal of Clinical Nutrition (2010). Doi:10.1038/ejcn.2010.184
About Carotech Inc.
Carotech, incorporated in 1990, is a public listed company in Malaysia (ACE Market). It was the first producer in the world of natural full spectrum tocotrienol/tocopherol complex (Tocomin® & Tocomin®SupraBio™), natural mixed carotene complex (Caromin®) and phytosterol complex (Stelessterol™) via its patented technology (US Patent Nos. 5,157,132 & 7,544,822).
Besides being the largest producer of tocotrienol, Carotech is also the only GMP-Certified tocotrienol producer in the world.
Tocomin®SupraBio™ is a patented (US Patent No. 6,596,306) self emulsifying palm tocotrienol complex that ensures optimal tocotrienols oral absorption.
Carotech is a subsidiary of Hovid Ltd (www.hovid.com), one of the largest GMP-certified pharmaceutical companies in Malaysia.
Carotech manufactures these products under the tradenames: Tocomin®, Tocomin®SupraBio™, Caromin® and Stelessterol™.
Websites: www.carotech.net and www.tocotrienol.org
Contacts:
Mr. Bryan See, Regional Product Manager, Carotech Inc, USA. Tel: +1(732) 906 1901
E-mail : klsee@carotech.net
Dr Sharon Ling, Vice President, Scientific Affairs, Europe Sales and Marketing. Tel : +44 (0) 1296 623 214
E-mail : sling@carotech.net
Mr WH Leong, Vice President, Carotech Pty. Ltd (Australia). Tel : +61 (03) 98013881
E-mail : carot3@aol.com
###
Contact
Carotech Inc.
ChoyMun Lai
+6052014192
www.carotech.net
Bryan See (Regional Product Manager)
+17329061901
klsee@carotech.net
ChoyMun Lai
+6052014192
www.carotech.net
Bryan See (Regional Product Manager)
+17329061901
klsee@carotech.net
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