Creative Biomart Launches Controlled Randomization Service for Random Nucleotide Substitutions
The GenePowerTM Controlled Randomization technology allows you to accurately direct the effective frequency of random nucleotide substitutions. And unlike error-prone PCR, you decide exactly which part(s) of the gene are affected—randomize the entire open reading frame or confine the mutagenesis to specific regions.
New York, NY, August 24, 2013 --(PR.com)-- Randomized constructs are rigorously controlled to help ensure that the unchanged portions of the sequence are unaffected and that randomized portions contain the distribution of nucleotides you require to encode the amino acid composition you're looking for.
Applications
• Diversify antigen-binding sites of antibodies
• Improve physicochemical protein properties such as solubility, heat stability, and activity in industrial environments
• Enhance function, such as promoter activity and enzymatic properties
• Optimize antibody affinity (in vitro affinity maturation)
• Humanize antibodies
• Prolong half-life of therapeutics for in vivo environments
• Improve enzymes for industrial use
• Modify enantioselectivity of enzymes
• Induce changes to alter proteins from patented sequences
Advantages
• Library diversity of up to 1011 variants
• Precise selection of the average mutation rate (number of changes per construct)
• Random mutagenesis throughout construct, or limited to defined positions
• Transition/transversion ratio of 1:2
• Fewer silent mutations
• Low ancillary mutation rate
• Fast production times
About Creative Biomart
Creative Biomart is a global full-service biotechnology company with profound expertise and experience in offering recombinant proteins, antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes, Elisa Kits, biosimilar cell lines, transfected stable cell lines etc. to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development. Visit http://www.creativebiomart.net/Random-Substitutions.htm for more information.
Contacts
Enquiry line: 1-631-559-9269
Website: www.creativebiomart.net
Email: info@creative-biomart.com or contact@creative-biomart.com
Applications
• Diversify antigen-binding sites of antibodies
• Improve physicochemical protein properties such as solubility, heat stability, and activity in industrial environments
• Enhance function, such as promoter activity and enzymatic properties
• Optimize antibody affinity (in vitro affinity maturation)
• Humanize antibodies
• Prolong half-life of therapeutics for in vivo environments
• Improve enzymes for industrial use
• Modify enantioselectivity of enzymes
• Induce changes to alter proteins from patented sequences
Advantages
• Library diversity of up to 1011 variants
• Precise selection of the average mutation rate (number of changes per construct)
• Random mutagenesis throughout construct, or limited to defined positions
• Transition/transversion ratio of 1:2
• Fewer silent mutations
• Low ancillary mutation rate
• Fast production times
About Creative Biomart
Creative Biomart is a global full-service biotechnology company with profound expertise and experience in offering recombinant proteins, antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes, Elisa Kits, biosimilar cell lines, transfected stable cell lines etc. to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development. Visit http://www.creativebiomart.net/Random-Substitutions.htm for more information.
Contacts
Enquiry line: 1-631-559-9269
Website: www.creativebiomart.net
Email: info@creative-biomart.com or contact@creative-biomart.com
Contact
Creative Biomart
Dynah Luo
(1)-516-669-8109
http://www.creativebiomart.net/
Dynah Luo
(1)-516-669-8109
http://www.creativebiomart.net/
Contact
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