Kingfisher Biotech’s Mouse GM-CSF Protein Found to be 40% More Active Than Competitor’s Mouse GM-CSF Protein.

Saint Paul, MN, October 28, 2013 --(PR.com)-- Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Granulocyte macrophage–colony stimulating factor (GM-CSF) is secreted in response to inflammatory stimuli such as LPS, IL-1, and TNF-α by a variety of different cells, including endothelium, fibroblasts, muscle cells, and macrophages, and by activated T cells. GM-CSF is glycosylated in its mature form.

Kingfisher Biotech’s mouse GM-CSF protein has been shown to be a superior product for use in cell culture. It is 40% more active than another commercially available mouse GM-CSF as measured by an independent testing laboratory. The biological activity of recombinant mouse GM-CSF was measured in a cell proliferation assay using the mouse FDC-P1 cell line. The ED50 for this effect was determined to be 0.0015-0.0023 ng/mL as compared to 0.0021-0.0035 ng/mL for the competitor’s mouse GM-CSF protein.

Mouse GM-CSF protein was produced in yeast without the use of tags. Proteins produced in yeast are naturally endotoxin free, properly folded, biologically active, and may be post-translationally modified. Many scientists find that these properties make proteins produced in yeast preferable over E. coli-produced proteins.

Mouse GM-CSF is lyophilized, available in convenient sizes (5, 25, and 100 micrograms) and in-stock ready to ship. Additional information, including product specifications and ordering information can be found at http://www.kingfisherbiotech.com.

Kingfisher Biotech is focused on providing kits and reagents to the animal health and animal model research community. Currently, the Kingfisher Biotech product portfolio contains over 750 products. Kingfisher Biotech products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use.