Je H. Lee from Cold Springs Harbor Laboratory Will Discuss, “Spatial Transcriptomics and Beyond” at GTCbio’s 6th Next Generation Sequencing

Boston, MA, February 18, 2016 --(PR.com)-- Je H. Lee, Assistant Professor at Cold Springs Harbor Laboratory will discuss, “Spatial Transcriptomics and Beyond” at GTCbio’s 6th Next Generation Sequencing to be held on May 25-26, 2016 in Boston, MA.

The Lee lab at CSHL is advancing in situ technologies, originally developed in the Church lab at Harvard to ask what the defining genetic and phenotypic traits are in mouse limb development and brain cancer cell evolution. The new in situ sequencing technology in the Lee lab can now interrogate specific RNA targets, including miRNA, anti-sense RNA, and other types of non-coding RNA, with subcellular resolution with over 100x higher sensitivity, and they are also developing methods to sequence specific CpG loci after bisulfite treatment in situ. Dr. Lee will also discuss the importance of RNA subcellular localization in defining cell types and the importance of unbiased transcriptomics approach to understanding the rule. Using these tools, he will describe their effort to study the genetic and epigenetic basis of histopathological hallmarks in cancer, and visualizing the transcriptome in the spatial frequency domain to investigate the relationship between diffusible activators and inhibitors in tissue patterning.

Dr. Lee received his MD.,PhD. from Tufts School of Medicine in the Department of Cellular and Molecular Physiology. His doctoral research focused on the role of single cell variations in tissue patterning and cancer biology. He then trained in internal medicine at the Hospital of University of Pennsylvania before joining the laboratory of Dr. George Church at Harvard. He was involved in developing various sequencing technologies with a specific focus on single cell and spatial transcriptomics. He worked as a staff scientist at the Wyss Institute for Bioengineering for two years before joining the Cold Spring Harbor Laboratory as a faculty member in 2014. His lab studies the spatial heterogeneity of gene expression and methylation in low-grade glioma and the spatial interaction among genetic elements during mouse digit patterning.

The 6th Next Generation Sequencing Conference will provide attendees with a better understanding of developments in new next generation sequencing technologies alongside clinical applications. There will be a focus on medical sequencing for patient characterization in targeted therapies through vast methods like single cell and RNA sequencing. Implications for how diseases should be treated will be discussed through the examination of data produced from reputable assays.

This conference is also part of the larger Genomics & Big Data Summit, which consists of three additional conferences including this meeting:
6th Next Generation Sequencing
3rd Metabolomics - Advances & Applications in Human Disease Conference
CRISPR & Genome Engineering
Big Data Bioinformatics

For more information please visit the website: www.gtcbio.com/ngs/agenda

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